Endocrine Abstracts

Introduction and methods: Controversy exists regarding the optimal dosing regimen of radioactive iodine (RAI) for the treatment of hyperthyroidism. The dose of RAI was individualised, based on the size of the thyroid gland and 24-h RAI uptake. We performed a 10-year retrospective analysis of patients with hyperthyroidism treated with variable dose RAI, with a cure defined as eu- or hypothyroidism.Results: One hundred and forty-nine patients with hyperthy...

Background Disturbances of calcium metabolism are frequent in patients with untreated hyperthyroidism, however they are typically mild and asymptomatic (1).Methods We describe a case of a 56-year-old female who presented with severe, symptomatic hypercalcaemia and hyperthyroidism secondary to Grave's disease. She initially presented with symptoms of weight loss, generalised malaise and lethargy. Investigations revealed hyperthyroidism and a positive TSH ...

Introduction: Lymphocytic hypophysitis is a rare autoimmune disease predominantly affecting females in the antepartum and postpartum period. It is characterized by destruction and lymphocytic infiltration of predominantly adenohypophysis with various degrees of hypopituitarism. Posteriour pituitary gland involvement is rare but has been reported. We report a case of a 32 year old lady who presented with diabetes insipidus and hypoadrenalism.Case: A 32 year old lady complai...

ObjectiveMeasurement of insulin sensitivity has always been a key interest in the clinical investigation of Type 2 diabetes mellitus. Previous studies have shown good correlation between the Oral Glucose Insulin Sensitivity (OGIS) Model and the gold standard euglycaemic hyperinsulinaemic glucose clamp. This study is to describe OGIS as an index for insulin sensitivity derived from glucose-insulin model in a clinical setting.Methods468 non-diabetes patients and 224 ...

Introduction: Diabetes ketoacidosis (DKA) remains a significant cause of mortality and morbidity in patients with diabetes. We reviewed all DKA episodes occurring in a large inner city teaching hospital between January 1997 and December 2001.Methods: A retrospective chart analysis was performed on 108 episodes of DKA identified through hospital inpatients enquiry (HIPE). DKA was defined as the triad of hyperglycaemia, ketonuria and acidosis with pH<7.35. All patients ha...

Introduction: We report a patient with a solitary fibrous mesothelioma producing insulin -like growth factor (IGF) II who presented with recurrent episodes of early morning acute disorientation and agitation. .On examination he was noted to have decreased air entry at the right base and midzone and a mass in the right hypochondrium. . Radiologic imaging showed a large pleural based mass which almost completely filled the right hemithorax. When symptomatic hypoglycaemia was...

Introduction: The incidence of diabetes is increasing worldwide and type 2 diabetes in younger people is a growing phenomenon. From 1998 we have studied 21 subjects with early onset type 2 diabetes.Methods:11 subjects(7 males) with type 2 diabetes, age 23.7 plus/minus 1.01 years and 10 subjects(8 males) age 35.4 plus/minus 11.7 years were studied with an insulin modified (0.05 unit per kg ) intravenous glucose tolerance test. BMI was 34.3 plus/minus 1.4 kg per m2</sup...

Background and Aims:Over the next decade, the projected epidemic of Diabetes, their subsequent treatment requirements and complication management will emerge as a major threat to future public health. There are always demands for greater efficiency and cost-effectiveness within healthcare service especially in the bigger scale population study. Our aim is to develop a computerized system to facilitate diagnosis of Diabetes mellitus through co-ordination of multiple healthc...